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The modifications reduce binding to IGF binding proteins, extending its biological half-life relative to native IGF-1

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The transferrin receptor (TfR) functions as the primary receptor for cellular iron uptake, binding to iron-containing ligands to form Tf-Fe complexes, thereby initiating the process of iron uptake [15]

Typical daily range: 2050 mcg once daily subcutaneously (gradual titration recommended)

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